代表性论文
1.(封面文章）Li N, van Unen V, Abdelaal T, Guo N, Kasatskaya SA, Ladell K, McLaren JE, Egorov ES, Izraelson M, Chuva de Sousa Lopes SM, Höllt T, Britanova OV, Eggermont J, de Miranda NFCC, Chudakov DM, Price DA, Lelieveldt BPF, Koning F*; Memory CD4+ T cells are generated in the human fetal intestine,Nature Immunology, 2019, 20(3): 301-312.（IF:27.7，1区TOP，Nature Immunology新闻与观点”（news&views）同期专题报道，2019年Nature Reviews Immunology亮点文章之一）
2.（封面文章）Li N#, van Unen V#, Höllt T, Thompson A, van Bergen J, Pezzotti N, Eisemann E, Vilanova A, Chuva de Sousa Lopes SM, Lelieveldt BPF, Koning F*;Mass cytometry reveals innate lymphoid cell differentiation pathways in the human fetal intestine,Journal of Experimental Medicine, 2018, 215(5): 1383-1396.（IF:15.3，1区TOP）
3.Song Y#,Li N#, Jiang S#, Wang K#, Lv G, Fan Z, Du X, Gao W, Lei L, Wang Z, Liu G, Li X*;Microbiota-derived H2S induces c-kit+ cDC1 autophagic cell death and liver inflammation in metabolic dysfunction-associated steatohepatitis.NatureCommunications. 2025,16(1):2222.（IF:15.7，1区TOP）
4.Jiang X#, Wang J#, Gan L, Wu Z, Wu T, Li F, Xu X, Lei L*,Li N*;Carbon dot-based treatment for bacterial pneumonia by promoting a PI3K-mediated M1 polarization of macrophages.Journal ofNanobiotechnology. 2025,26;23(1):315.（IF:12.6，1区TOP）
5.Jia L#,Li N#, Abdelaal TRM, Guo N, IJsselsteijn ME, van Unen V, Lindelauf C, Jiang Q, Xiao Y, Pascutti MF, Hiemstra PS, Koning F, Stolk J, Khedoe PPSJ*; High-dimensional mass cytometry reveals emphysema-associated changes in the pulmonary immune system,American Journal of Respiratory and Critical Care Medicine, 2024.（IF:19.3，1区Top）
6.Jiang X#, Mei J#, Zhu J, Tian Y, Wu T, Li Z, Wu Z, Abdelaal T, Li F,Li N*, Lei L*; A single-cell atlas of mouse central nervous system immune cells reveals unique infection-stage immune signatures during the progression of meningitis caused by Streptococcus suis.CommunicationsBiology. 2025,8(1):1312.（IF:5.8，1区Top）
7.Mei J#, Jiang X#, Li F, Wu Z, Tong Wu, Zhu J, Jiang H, Li Z,Li N*, Lei L*;Streptococcus suis serotype 2 collagenase-like protease promotes meningitis by increasing blood-brain barrier permeability,Journal of Integrative Agriculture, 2025,24(11):4379-4394（IF:4.6，1区TOP）
8.Yang Q#,Li N#, Zheng Y, Tian Y, Liang Q, Zhao M, Chu H, Gong Y, Wu T, Wei S, Wang H, Yan G, Li F*, Lei L*; Identification and characterization of ugpE associated with the full virulence of Streptococcus suis.Veterinary Research. 2025,56(1):82.（IF:3.5，1区）
9.Li N, Zhu J, Chen P, Bao C, Wang J, Abdelaal T, Chen D, Zhu S, Wang W, Mao J, Scicluna BP, Koning F, Li F*, Lei L*; High-dimensional analysis reveals an immune atlas and novel neutrophil clusters in the lungs of model animals with Actinobacillus pleuropneumoniae-induced pneumonia,Veterinary Research, 2023, 54(1).（IF:3.7，1区TOP）
10.Bao C#, Jiang X#, Tian Y, Wang W, Xiao J, Liu B, Chen P, Li Z, Li J, Zhu J, Abdelaal T, Chen D,LiN*, Lei Li*;IL-21-dependent Ly6C+Ly6G+CD4+ T cells found in lung enhance macrophages function against Actinobacillus pleuropneumoniae infection in mice.Cell Death Discovery.2025,11(1):440.（IF:7.0，2区TOP）
11.Tian Y#, Jiang X#, Bao C, Abdelaal T, Chen D, Wang W, Li F, Lei L*,Li N*;Mass cytometry analysis reveals a cross-tissue immune landscape in Actinobacillus pleuropneumoniae-induced pneumonia.Microbiology Spectrum.2025,13(6):e0266524（IF:3.8，2区）
12.Wu T, Jiang H, Li F, Jiang X, Wang J, Wei S, Sun Y, Tian Y, Chu H, Shi Y, Zhang N,Li N*, Lei L*;O-acetyl-homoserine sulfhydrylase deficient Streptococcus suis serotype 2 strain SC19 becomes an avirulent strain and provides immune protection against homotype infection in mice.VeterinaryMicrobiology. 2024, 288:109943.（IF:2.4，1区）
13.Wang J, Gan L, Li F, Li Q, Wu T, Wu Z, Chen P, Scicluna BP, Feng X, Gu J, Han W,Li N*, Lei L*;Tracheal epithelial cell-exosome-derived MiR-21-5p inhibits alveolar macrophage pyroptosis to resist pulmonary bacterial infection through PIK3CD-autophagy pathway.Life Sciences,2024, 1;336:122340.（IF:5.2，2区TOP）
14.Jiang X#, Li F#, Mei J, Wu T, Zhu J, Li Z, Wu Z, Jiang H,Li N*, Lei L*;Brain Immune Cell Infiltration and Serum Metabolomic Characteristics Reveal that Lauric Acid Promotes Immune Cell Infiltration in Brain and Streptococcus suis Meningitis in Mice,Molecular Neurobiology, 2024,（IF:4.6，2区）
15.Wu Z#,Li N#, Li Z, Wang J, Liu M, Qi M, Wei S, Wu T, Guo Y, Zhu J, Jiang H, Xue R, Sun C, Feng X, Gu J, Han W, Li F*, Lei L*;Development and application of an indirect ELISA and nested PCR for the epidemiological analysis of Klebsiella pneumoniae among pigs in China.Frontiers in Microbiology,2024 Jan 8;14:1329609.（IF:4.0，2区TOP）
16.Zhu J, Zhu R, Jiang H, Li Z, Jiang X, Li F, Zhang F, Feng X, Gu J,Li N*, Lei L*;AdhPromotes Actinobacillus pleuropneumoniae Survival in Porcine Alveolar Macrophages by Inhibiting CHAC2-Mediated Respiratory Burst and Inflammatory Cytokine Expression.Cells.2023,22;12(5):696.（IF:5.1，2区）
17.Chen P, Bao C, Zhu R, Wang J, Zhu J, Li Z, Li F, Gu J, Feng X,Li N*, Lei L*; IL-5 enhances the resistance of Actinobacillus pleuropneumoniae infection in mice through maintaining appropriate levels of lung M2, PMN-II and highly effective neutrophil extracellular traps,Veterinary Microbiology, 2022, 269:109438.（IF:2.4，1区）
18.Bao C#, Liu B#, Zhu R, Xiao J, Li Z, Jiang H, Wang B, Langford PR, Fei R,Li N*, Lei L*; IFN-γ-/-mice resist Actinobacillus pleuropneumoniae infection by promoting early lung IL-18 release and PMN-I accumulation,Infection and Immunity, 2021,17;89(6):e00069-21.（IF:2.9）
19.Sun Q#,Li N#, Jia L, Guo W, Jiang H, Liu B, Bao C, Liu M, Huang J*, Lei L*; Ribosomal Protein SA-Positive Neutrophil Elicits Stronger Phagocytosis and Neutrophil Extracellular Trap Formation and Subdues Pro-Inflammatory Cytokine Secretion Against Streptococcus suis Serotype 2 Infection,Frontiers in Immunology, 2021,11:585399.（IF:5.1，2区）
20.Jiang H, Wu T, Liu J, Yu X, Liu H, Bao C, Liu M, Ji Y, Feng X, Gu J, Han W,Li N*, Lei L*; Caveolae/rafts protect human cerebral microvascular endothelial cells from Streptococcus suis serotype 2 α-enolase-mediated injury,Veterinary Microbiology, 2021, 254: 108981.（IF:2.4，1区）
21.Liu M#,Li N#, Guo W, Jia L, Jiang H, Li Z, Wang J, Zhang X, Zhu R, Bao C, Huang J*, Lei L*; RPSA distribution and expression in tissues and immune cells of pathogen-infected mice,Microbial Pathogenesis,2021, 152:104609.（IF:3.3）
22.Guo N, van Unen V, Ijsselsteijn ME, Ouboter LF, van der Meulen AE, Chuva de Sousa Lopes SM, de Miranda NFCC, Koning F*,Li N*; A 34-Marker Panel for Imaging Mass Cytometric Analysis of Human Snap-Frozen Tissue,Frontiers in Immunology, 2020, 11:1466.（IF:5.1，2区）
23.Li N, van Unen V, Guo N, Abdelaal T, Somarakis A, Eggermont J, Mahfouz A, Chuva de Sousa Lopes SM, Lelieveldt BPF, Koning F*; Early-Life Compartmentalization of Immune Cells in Human Fetal Tissues Revealed by High-Dimensional Mass Cytometry,Frontiers inImmunology, 2019, 10: 1932.（IF:5.1，2区）
24.Song Y#,Li N#, Gu J, Fu S, Peng Z, Zhao C, Zhang Y, Li X, Wang Z, Li X, Liu G;β-Hydroxybutyrate induces bovine hepatocyte apoptosis via an ROS-p38 signaling pathway. 2016, 11, 9184-9198.Journal of Dairy Science（IF:3.7，1区TOP，ESI高被引文章）
25. van Unen V,Li N, Molendijk I, Temurhan M, Höllt T, van der Meulen-de Jong AE, Verspaget HW, Mearin ML, Mulder CJ, van Bergen J, Lelieveldt BP, Koning F*; Mass Cytometry of the Human Mucosal Immune System Identifies Tissue- and Disease-Associated Immune Subsets,Immunity, 2016, 44(5): 1227-1239.（IF:25.5，1区Top）
